Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle
نویسندگان
چکیده
منابع مشابه
Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.
Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass. When these atrophy-related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates musc...
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Muscle atrophy increases the production of reactive oxygen species and the expression of atrophy-related genes, which are involved in the ubiquitin-proteasome system. In the present study, we investigated the effects of β-carotene on oxidative stress (100 μM-H2O2)-induced muscle atrophy in murine C2C12 myotubes. β-Carotene (10 μM) restored the H2O2-induced decreased levels of myosin heavy chain...
متن کاملDifferential expression of sarcoplasmic and myofibrillar proteins of rat soleus muscle during denervation atrophy.
Denervation is known to induce skeletal muscle atrophy and fiber-type transitions, the molecular mechanisms of which are poorly understood. To investigate the effect of denervation on skeletal muscle, proteomic analysis was performed to compare denervated soleus muscle with normal soleus muscle. The muscles were fractionated to myofibrillar and sarcoplasmic fractions, which were analysed using ...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2011
ISSN: 0730-2312
DOI: 10.1002/jcb.23136